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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 942-942 doi: 10.1007/s11684-021-0876-z

The impact on expensive soil characteristics with different dosages of weathered sand of a highway in Yichang

Yang Jun,Li Xinchun,Zhang Guodong,Tang Yunwei,Xie Zhigang,Guo Daoyi

Strategic Study of CAE 2012, Volume 14, Issue 11,   Pages 57-62

Abstract:

Aiming at widespread presence of expansive soil which canbe obtained in the project from Xiaoxita to Yaqueling first-class highway rebuilding engineering in Yichang City of Hubei Province and weathered sand which can be made full use of locally, many experiments were made. Compaction experiments and expansibility index indoor experiments of undisturbed expansive soil and expansive soil mixed with sand range from 10 % to 50 % were made. Through the test of undisturbed expansive soil mixed with different content of weathered sand, it was found that undisturbed expansive soil mixed with weathered sand can change the expansive soil water characteristics and compaction characteristics. Undisturbed expansive soil mixed with different content of weathered sand can influence the expansibility of the expansive soil index and significantly inhibit the expansibility of the expansive soil and reach the standard of roadbed filler.

Keywords: xpansive soil     weathered sand     expansion indicator     compaction test    

Screening of indicator pharmaceuticals and personal care products in landfill leachates: a case study

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 9, doi: 10.1007/s11783-023-1716-y

Abstract:

● A systematic framework was developed to identify i-PPCPs for landfill leachate.

Keywords: Landfill leachates     PPCPs     Indicator     Screening criteria     Source-specificity    

Investigating the role of exiting vehicles and turn indicator usage in gap acceptance at single-lane

Nathan P. BELZ

Frontiers of Structural and Civil Engineering 2017, Volume 11, Issue 1,   Pages 8-16 doi: 10.1007/s11709-016-0365-7

Abstract: Results prompt the consideration of more consistent guidance on and enforcement of turn indicator use

Keywords: roundabouts     exiting vehicles     turn indicator use     headways    

Modeling effects of a tidal barrage on water quality indicator distribution in the Severn Estuary

Guanghai GAO, Roger A. FALCONER, Binliang LIN

Frontiers of Environmental Science & Engineering 2013, Volume 7, Issue 2,   Pages 211-218 doi: 10.1007/s11783-012-0464-1

Abstract: to assess the impacts of proposed Severn Barrage on the hydrodynamic, sediment transport and faecal indicator

Keywords: water quality indicator     Severn Estuary     numerical model     tidal energy    

A MATLAB code for the material-field series-expansion topology optimization method

Frontiers of Mechanical Engineering 2021, Volume 16, Issue 3,   Pages 607-622 doi: 10.1007/s11465-021-0637-3

Abstract: This paper presents a MATLAB implementation of the material-field series-expansion (MFSE) topo-logy optimizationWith the series-expansion method for bounded fields, this material field is described with the characteristic

Keywords: MATLAB implementation     topology optimization     material-field series-expansion method     bounded material    

Assessment of bridge expansion joints using long-term displacement measurement under changing environmental

Youliang DING, Aiqun LI

Frontiers of Structural and Civil Engineering 2011, Volume 5, Issue 3,   Pages 374-380 doi: 10.1007/s11709-011-0122-x

Abstract: This paper addresses the problem of condition assessment of bridge expansion joints using long-term measurementThe effects of temperature, traffic loading and wind on the expansion joint displacements are analyzedStatistical process control using mean value control charts is further used to detect damage to the bridge expansionhad a good capability for detecting the damage-induced 1.0% variances of the annual changes in the expansion

Keywords: structural health monitoring     displacement     expansion joint     temperature effect     wind effect     traffic loading    

Water environment security indicator system for urban water management

Tian HAO, Pengfei DU, Yun GAO

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 5,   Pages 678-691 doi: 10.1007/s11783-012-0450-7

Abstract: environment management, a systematic approach, encompassing several steps including establish ideal indicatorand organize discussion workshop, should be followed to establish a comprehensive water environment indicatorrelating to water environment security as well as design an appropriate water environment security indicator

Keywords: water environment security     supervision and management     monitoring parameter     indicator system     Suzhou    

An approach for evaluating the impact of an intermittent renewable energy source on transmission expansion

Rongrit CHATTHAWORN,Surachai CHAITUSANEY

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 10,   Pages 871-882 doi: 10.1631/FITEE.1500049

Abstract: optimization approach to evaluate the impact of an intermittent renewable energy source on transmission expansionscenarios representing the intermittent renewable energy generation and loads is proposed to obtain robust expansionMoreover, the impact of an intermittent renewable energy source on TEP was evaluated by comparing expansion

Keywords: Adaptive tabu search     Renewable energy generation     Robust optimization     Transmission expansion planning    

Achieving desired nodal lines in freely vibrating structures via material-field series-expansion topology

Frontiers of Mechanical Engineering 2023, Volume 18, Issue 3, doi: 10.1007/s11465-023-0758-y

Abstract: In this study, an effective material-field series-expansion (MFSE)-based topology optimization design

Keywords: nodal line     topology optimization     structural dynamics design     material-field series-expansion    

China’s Agriculture Green Development: from Concept to Actions

Frontiers of Agricultural Science and Engineering doi: 10.15302/J-FASE-2023512

Abstract:

● A target-threshold indicator evaluation system is proposed to measure

Keywords: agricultural transformation     Agriculture Green Development     historical trend     indicator system     theoretical    

Numerical simulation of sudden-expansion two-phase flows with two-scale second-order moment particle

ZENG Zhuoxiong, HAN Shoulei, ZHOU Lixing

Frontiers in Energy 2007, Volume 1, Issue 2,   Pages 202-206 doi: 10.1007/s11708-007-0026-6

Abstract: The model is employed to simulate gas-particle flows in a sudden-expansion chamber.

Keywords: gas-particle     single-scale second-order     large-scale fluctuation     second-order     sudden-expansion    

Research on Expansion Theory of Ammonium Nitrate

Lü Chunxu

Strategic Study of CAE 2001, Volume 3, Issue 9,   Pages 58-63

Abstract:

In this paper, expansion process of AN is described, its physical chemical parameters are calculatedand determined, the influeucing factors of AN expansion process are studied and a possible mechanismof expansion process is also given.

Keywords: expanded ammonium nitrate     expansion theory     physical chemical parameter     influencing factor    

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Lan Wang,Jueheng Wu,Jie Yuan,Xun Zhu,Hongmei Wu,Mengfeng Li

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 41-51 doi: 10.1007/s11684-016-0429-z

Abstract:

Midline2 (MID2) is an ubiquitin-conjugating E2 enzyme linked to tumor progression and a novel interacting partner of breast cancer 1, early-onset (BRCA1). However, the role of MID2 in breast cancer remains unknown. This study investigated the expression, prognostic value, and role of MID2 in breast cancer. The expression of MID2 mRNA and protein was significantly upregulated in breast cancer tissue and established cell lines compared with that in normal breast epithelial cells and paired adjacent non-tumor tissue (P<0.001). Immunohistochemical analysis demonstrated that MID2 was overexpressed in 272 of 284 (95.8%) paraffin-embedded, archived breast cancer tissue. Moreover, MID2 expression increased with advanced clinical stage (P<0.001). High MID2 expression was significantly associated with advanced clinical stages and T, N, and M staging (all P<0.05). Univariate and multivariate analyses indicated that high MID2 expression was an independent prognostic factor for poor overall survival in the entire cohort (93.73 vs. 172.1 months; P<0.001, log-rank test) and in subgroups with stages Tis+ I+ II and III+ IV. Furthermore, 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide colony formation, and anchorage-independent growth ability assays were conducted. Results showed that siRNA silencing of MID2 expression significantly reduced MCF-7 and MDA-MB-231 cell proliferation in vitro and blocked the growth of MDA-MB-231 cell xenograft tumors in vivo (P<0.05). This study indicated that MID2 may be a novel prognostic marker and interventional target in breast cancer.

Keywords: breast cancer     MID2     proliferation     overall survival     xenograft    

Modelling autogenous expansion for magnesia concrete in arch dams

JIN Feng, LUO Xiaoqing, ZHANG Chuhan, ZHANG Guoxin

Frontiers of Structural and Civil Engineering 2008, Volume 2, Issue 3,   Pages 211-218 doi: 10.1007/s11709-008-0025-7

Abstract: To evaluate the effects of autogenous expansion on the stresses of arch dams, a simple model of autogenousexpansion for Magnesia Concrete in dam engineering is presented.This model is based on three assumptions: 1) the total amount of autogenous expansion of Magnesia Concreteis related only to the properties of materials and mixing of concrete; 2) the autogenous expansion ofelement arch dam simulation software, this model is employed to simulate the effects of autogenous expansion

Keywords: field-measured     irreversibility     temperature     irreversible     element arch    

Title Author Date Type Operation

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Journal Article

The impact on expensive soil characteristics with different dosages of weathered sand of a highway in Yichang

Yang Jun,Li Xinchun,Zhang Guodong,Tang Yunwei,Xie Zhigang,Guo Daoyi

Journal Article

Screening of indicator pharmaceuticals and personal care products in landfill leachates: a case study

Journal Article

Investigating the role of exiting vehicles and turn indicator usage in gap acceptance at single-lane

Nathan P. BELZ

Journal Article

Modeling effects of a tidal barrage on water quality indicator distribution in the Severn Estuary

Guanghai GAO, Roger A. FALCONER, Binliang LIN

Journal Article

A MATLAB code for the material-field series-expansion topology optimization method

Journal Article

Assessment of bridge expansion joints using long-term displacement measurement under changing environmental

Youliang DING, Aiqun LI

Journal Article

Water environment security indicator system for urban water management

Tian HAO, Pengfei DU, Yun GAO

Journal Article

An approach for evaluating the impact of an intermittent renewable energy source on transmission expansion

Rongrit CHATTHAWORN,Surachai CHAITUSANEY

Journal Article

Achieving desired nodal lines in freely vibrating structures via material-field series-expansion topology

Journal Article

China’s Agriculture Green Development: from Concept to Actions

Journal Article

Numerical simulation of sudden-expansion two-phase flows with two-scale second-order moment particle

ZENG Zhuoxiong, HAN Shoulei, ZHOU Lixing

Journal Article

Research on Expansion Theory of Ammonium Nitrate

Lü Chunxu

Journal Article

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Lan Wang,Jueheng Wu,Jie Yuan,Xun Zhu,Hongmei Wu,Mengfeng Li

Journal Article

Modelling autogenous expansion for magnesia concrete in arch dams

JIN Feng, LUO Xiaoqing, ZHANG Chuhan, ZHANG Guoxin

Journal Article